The HighPrep RNA Elite system utilizes MagBio’s solid-phase paramagnetic bead technology for high-throughput purifi cation of RNA or cDNA for in vitro applications such as transcription, antisense RNA (aRNA) amplifi cation as well as RNA and cDNA probe synthesis. This protocol enables recovery of micro RNA (miRNA), small RNA and total RNA from enzymatic reactions, concentrating miRNA and total RNA from a diluted sample. This protocol can be used for manual procedure as well as guideline for adapting the kit to automatic liquid handling instruments.